That being said, here are 8 diseases that are fairly common and understood. Not to say that everyone knows how to prevent TVS, but a city doctor or priest can certainly be paid to help facilitate curing it.
1. Lobster-Dick. Your genitals become replaced with a lobster tail, complete with shell, tiny legs, and all the accoutrements. It's still functional. Gain a +1 bonus to save vs. groin attacks. If you have intercourse with someone (regardless of your sex or theirs) they become pregnant, and give birth to 1d6 lobster-men. Interestingly, this curse can be used on other body parts, but to less drastic effect (gaining a giant pincer is cool, and most adventurers can't write anyway).
How did you get it? Defiling the temple of a sea-god, or doing something truly reprehensible to a lobster. You fucking sicko.
How do you cure it? You can't. Sorry.
2. Spell Syphilis. Your mind begins to slip, and your spell slots rot right out of your head. Eventually, you die, but in the meantime you go crazy and become a stereotypical "mad wizard". Your aura, if viewed through a shew-stone or a spell like second sight, looks like a ratty old cloak made of bacteria or fungus, and you look like a living corpse. Spell slots rot at rate of 1 per day, then you start taking Wisdom damage. At 0 you die.
How did you get it? Handling any strange wands, especially those found in a dungeon.
How do you cure it? It's incurable, but you can stave off the effects by passing it on to someone else, a la It Follows.
3. Excessive Sanguinity. You have too much blood! For the first few days after contracting this illness you feel fucking great, and gain +2 to Dexterity and Strength checks, but then it starts to hurt as your veins swell and fill, with no extra space to grow to. After nearly two weeks of excrutiating agony, you pop. In that time, any being that feeds on blood (vampires, blood mages, mosquitoes) within a five mile radius knows exactly where you are.
How did you get it? Eating too many blood oranges, coming into contact with any bodily fluid already infected.
How do you cure it? Drain your blood to keep it in equilibrium, forever.
4. Spontaneous Osteo-Liquefaction. Your bones turn to liquid, usually in stages. First, the teeth liquefy and trickle down the back of the throat. Save vs choking. Then the extremities, the fingers, toes, and fontanelle, and you stop being able to hold things. Finally the main structural bones turn to liquid and you can't stand, or move quickly at all. You become a slime, of sorts.
How did you get it? Ingest the flesh of an ooze. It's a bit like lycanthropy, but grosser.
How do you cure it? Drink a bunch of milk. Bathe in milk. Sacrifice a finger to the calcium gods.
5. Scabification. Your blood begins to harden in your veins. It's slow enough that you definitely feel it, though not exactly what it is exactly. Something like arthritis or old knees, but it can affect a person of any age. Suffer a -5 penalty to all Dexterity checks. Eventually, your entire body becomes a rough, coagulated sculpture.
How did you get it? Picked too many scabs, or you didn't offer fealty to the minor spirits of bloodlust as you pass a battlefield.
How do you cure it? Drink a tincture of ground leeches and heparin, once a day for a week. The medicine makes you feel weak; -3 to your Constitution score until you stop taking it, and your save vs. poison is reduced.
6. Loss of Ontological Cohesion. Somehow, you or your body was convinced that it isn't really a human body. Your organs and tissues forget their purpose, turning into leaves and flowers and tadpoles and threads. You drift apart, your mind unravelling as your body does. Occasionally, you can remember who your were with enough fortitude so as to hold your new body together (like living armor) but this is rare. All of your physical stats begin to decrease as your body fades, and unless you pass a Wisdom save every day, so too does your mind.
How did you get it? Encountered a memetic virus, and Outsider or god thought about you too hard, or you got drunk and started talking philosophy.
How do you cure it? It can't be reversed, but you can halt it by reading anatomy textbooks and remembering bits of your past life.
7. TVS. Aka Terminal Velocity Syndrome. Once thought to be a combination of a vestibular issue and osteogenesis imperfecta, sufferers of TVS are affected by gravity at an abnormal rate. Every movement is compounded enough to instantly reach terminal velocity; even a fall from a foot or two up can be fatal. A stumble deals 1d6 damage, and all fall damage is multiplied by 5. Your attacks are a lot heavier, though, and deal +2 damage.
How did you get it? Struck on the head by a Stygian apple, or bitten by a gravity goblin.
How do you cure it? Remain suspended in an antigravity field for an hour a day.
8. Teakettler Disease. Your internal body temperature is constantly rising, causing pain and pressure on your bones. If you ignore it long enough without releasing it (roughly every three hours), you take 1d6 exploding heat damage. When you release it, it issues from your mouth in a burst of steam and a piercing whistle that can be heard from far away. Your sleep is rough and unsteady, and you gain 1/2 the XP you normally would.
How did you get it? You didn't offer a weary guest the customary drink, or touched a dragon's scale without washing it in grain alcohol first.
How do you cure it? Consume a cumulative 9 pounds of ice.
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